Scientists have created a drug that, with no danger of dependency or other side effects, can supply the exact same pain relief as opioid drugs, in rhesus monkeys.
He said that studies on people could begin within just two years.
The research team said the new drug may provide relief if you have long-term pain while additionally quelling the growing abuse of opioids, which account for many drug overdose deaths in America, in accordance with the Centers for Disease Control and Prevention.
Opioids have been used to provide pain relief. They contain codeine, morphine, heroin, and prescription drugs like OxyContin and Vicodin. A main goal for opioid drugs is a specific receptor called the mu opioid peptide receptor (MOP).
Opioids are highly addictive, yet, because these same opioid receptors that react to pain indicates additionally involved in modulating mental whims including the desire for euphoria, wages and cravings.
So, his co-workers and Ko took a double strategy by creating a drug analogue that may simultaneously target both NOP brain receptors and the MOP to generate opioid-like pain relief while reducing the danger of dependence.
The group of Ko really found that it created pain relief with no indications of being addictive and examined this in monkeys. The monkeys didn't self-administer the drug as they normally would with other addictive substances like cocaine or opioids, Ko told Live Science.
The drug analogue BU08028 additionally had no noticeable side effects, Ko said. On the other hand, opioids can cause leading causes of death, cardiac arrest and respiratory failure . Ko said that BU08028 failed to cause such side effects in monkeys at 10- to 30-times the dose needed to alleviate pain.
The research team has high hopes the BU08028 compound would not be ineffective in people.
"Nonhuman primates including rhesus monkeys have similar physiological reactions to opioid analgesics like people," Ko told Live Science which is also published at pain forum.
Ko included when making it that the one challenge in creating a successful drug for people may maintain optimizing the therapeutic effect of the drug. This would be an important focus of any clinical study as suggested at health message boards.